Tezuka T, Kumar D, Singh S, Koyanagi I, Naoi T and Sakaguchi M, Open-source, automatic, real-time sleep stage classification system using single EEG for mice, Sci Rep in printing, DOI: to be assigned


Yu J, Naoi T and Sakaguchi M, Fear generalization immediately after contextual fear memory consolidation in mice, BBRC 558:102-106, 2021, DOI:10.1016/j.bbrc.2021.04.072


Vergara P, Kumar D, Srinivasan S, Koyanagi I, Naoi T, Singh S and Sakaguchi M, Remapping of adult-born neuron activity during fear memory consolidation in mice, IJMS 22(6):2874, 2021, DOI:10.3390/ijms22062874


Ohba A and Sakaguchi M, Contribution of adult-born neurons to memory consolidation during REM sleep, Neural Regen Res, 2021, DOI: in printing


Koyanagi I, Sonomura K, Naoi T, Ohnishi T, Kaneko N, Sawamoto K, Sato T and Sakaguchi M, Metabolic fingerprints of fear memory consolidation during sleep, Mol Brain 14:30, 2021, DOI:10.1186/s13041-021-00733-6


Carrier-Ruiz A, Sugaya Y, Kumar D, Vergara P, Koyanagi I, Srinivasan S, Naoi T, Kano M and Sakaguchi M, Calcium imaging of adult-born neurons in freely moving mice, STAR Protocols 2(1):100328, 2021, DOI/10.1016/j.xpro.2020.100238


Vergara P and Sakaguchi M, Mechanisms underlying memory consolidation by adult-born neurons during sleep, Front Cell Neurosci 14(594401):1-7, 2020, DOI/10.3389/fncel.2020.594401


Kumar D, Koyanagi I¥, Carrier-Ruiz A¥, Vergara P¥, Srinivasan S¥, Sugaya Y, Kasuya M, Yu T, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, Wang S, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M and Sakaguchi M, Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation, Neuron 107:552-65, 2020, DOI:10.1016/j.neuron.2020.05.008, ¥equal contribution, Recommended by Faculty Opinions (DOI:10.3410/f.738073111.793578641, Nat Rev Neurosci (DOI:10.1038/s41583-020-0339-6) Link for accepted manuscript.


Maezono E.B.S, Kanuka M, Tatsuzawa C, Morita M, Kawano T, Kashiwagi M, Nondhalee P, Sakaguchi M, Saito T, Saido T and Hayashi Y, Progressive changes in sleep architecture and electroencephalogram in single App knock-in mice and its relations to amyloid-β distribution and learning abilities, eNeuro 7(2):1-14, 2020, DOI:10.1523/eneuro.0093-20.2020


Srinivasan S¥, Hosokawa T¥, Vergara P, Chérasse Y, Naoi T, Sakurai T and Sakaguchi M, Miniaturized microscope with flexible light source input for neuronal imaging and manipulation in freely behaving animals, BBRC 517:520-4, 2019, DOI:10.1016/j.bbrc.2019.07.082, ¥equal contribution


Koyanagi I, Akers KG, Vergara-García P, Srinivasan S, Sakurai T and Sakaguchi M, Memory consolidation during sleep and adult hippocampal neurogenesis, Neural Regen Res 14(1):20-23, 2019, DOI:10.4103/1673-5374.243695.


Akers KG, Chérasse Y, Fujita Y, Sakthivel S, Sakurai T and Sakaguchi M, Regulatory influence of sleep and epigenetics on adult hippocampal neurogenesis and cognitive and emotional function, Stem Cells 36:969-76, 2018. DOI:10.1002/stem.2815


Purple R, Sakurai T and Sakaguchi M, Auditory conditioned stimulus presentation during NREM sleep impairs fear memory in mice, Sci Rep 7:46247, 2017, DOI:10.1038/srep46247


Fujinaka A¥, Li R¥, Hayashi M, Kumar D, Changarathil G, Naito K, Miki K, Nishiyama T, Lazarus M, Sakurai T, Kee N, Nakajima S, Wang SH and Sakaguchi M, Effect of context exposure after fear learning on memory generalization in mice, Mol Brain 9:2, 2016, DOI:10.1186/s13041-015-0184-0, ¥equal contribution, undergraduates at the time, Research award from the president of the university.


Sakaguchi M, Kim K, Yu LMY, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ and Hayashi Y, Inhibiting the activity of CA1 hippocampal neurons prevents the recall of contextual fear memory in inducible ArchT transgenic mice, Plos ONE 10(6):e0130163, 2015, DOI:10.1371/journal.pone.0130163


Arruda-Carvalho M, Akers KG, Guskjolen AJ, Sakaguchi M, Josselyn S and Frankland PW, Post-training ablation of adult-generated olfactory granule cells degrades odor-reward memories, J Neurosci 19;34(47):15793-803, 2014


Sakaguchi M and Hayashi Y, Catching the engram: strategies to examine the memory trace, Mol Brain 5:32, 2012


Hirota Y, Sawada M, Kida Y, Huang SH, Yamada O, Sakaguchi M, Ogura T, Okano H and Sawamoto K, Roles of planar cell polarity signaling in maturation of neuronal precursor cells in the postnatal mouse olfactory bulb, Stem Cells 30(8):1726-33, 2012


Sakaguchi M and Okano H. Neural stem cells, adult neurogenesis and galectins: from bench to bedside, Dev Neurobiol 72(7):1059-67, 2012


Stone S, Teixeira CM, Zaslavsky K, Wheeler AL, Canabal AM, Wang AH, Sakaguchi M, Lozano AM, Frankland PW, Functional Convergence of Developmentally- and Adult- Generated Granule Cells in Dentate Gyrus Circuits Supporting Hippocampus-Dependent Memory, Hippocampus 21(12):1348-62, 2011


Arruda-Carvalho M, Sakaguchi M¥, Akers KG, Josselyn SA, Frankland PW, Post-training ablation of adult-generated neurons degrades previously-acquired memories, J Neurosci 31(42):15113-27, 2011, ¥equal contribution


Yamane J¥, Ishibashi S¥, Sakaguchi M¥, Kuroiwa T, Kanemura Y, Nakamura M, Miyoshi H, Sawamoto K, Toyama Y, Mizusawa H, Okano H, Transplantation of human neural stem/progenitor cells overexpressing Galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil, Mol Brain 4:35, 2011, ¥equal contribution


Sakaguchi M, Arruda-Carvalho M, Kang NH, Imaizumi Y, Poirier F, Okano H, Frankland PW, Impaired spatial and contextual memory formation in galectin-1 deficient mice, Mol Brain 4(1):33, 2011


Leslie AT, Akers KG, Krakowski A, Stone S., Sakaguchi M, Arruda-Calvalho M, Frankland PW, Impact of early adverse experience on complexity of adult-generated neurons, Transl Psych 1:e35, 2011


Imaizumi Y, Sakaguchi M, Morishita T, Ito M, Poirier F, Sawamoto K, Okano H, Galectin-1 is expressed in early-type neural progenitor cells and down-regulates neurogenesis in the adult hippocampus, Mol Brain 24:7, 2011


Ikeda M, Hirota Y, Sakaguchi M, Yamada O, Kida YS, Ogura T, Otsuka T, Okano H, Sawamoto K, Expression and Proliferation-Promoting Role of Diversin in the Neuronally Committed Precursor Cells Migrating in the Adult Mouse Brain., Stem Cells 28(11):2017-26, 2010


Hirota Y, Meunier A, Huang S, Shimozawa T, Yamada O, Kida YS, Inoue M, Ito T, Kato H, Sakaguchi M, Sunabori T, Nakaya M, Nonaka S, Ogura T, Higuchi H, Okano H, Spassky N, and Sawamoto K, Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II, Development 137(18):3037-46, 2010


Sakaguchi M, Imaizumi Y, Shingo T, Tada H, Hayama K, Yamada O, Morishita T, Kadoya T, Uchiyama N, Shimazaki T, Kuno A, Poirier F, Hirabayashi J, Sawamoto K, Okano H., Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction., J Neurochem 113(6):1516-24, 2010


Akers KG, Sakaguchi M, Arruda-Carvalho M, Functional contribution of adult-generated olfactory bulb interneurons: Odor discrimination versus odor memory, J Neurosci 30(13):4523-5, 2010


Yamane J, Nakamura M, Iwanami A, Sakaguchi M, Katoh H, Yamada M, Momoshima M, Miyao S, Ishii K, Tamaoki N, Nomura T, Okano HJ, Kanemura Y, Toyama Y, Okano H, Transplantation of Galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets, J Neurosci Res 88(7):1394-405, 2010


Frankland PW, Sakaguchi M, Arruda-Carvalho M, Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?, Mol Brain 1:5, 2008


Ishibashi S, Kuroiwa T, Sakaguchi M, Sun L, Kadoya T, Okano H, Mizusawa H, Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke, Exp Neurol 207(2):302-13, 2007


Okano H, Sakaguchi M, Ohki K, Suzuki N, Sawamoto K, Regeneration of the central nervous system using endogenous repair mechanisms, J Neurochem 102(5):1459-65, 2007


Adachi K, Mirzadesh Z, Sakaguchi M, Yamashita T, Nikolcheva T, Gotoh Y, Peltz G, Gong L, Kawase T, Alvarez-Buylla A, Okano H, Sawamoto K, β-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone, Stem Cells 25(11):2827-36, 2007


Sakaguchi M, Imaizumi Y and Okano H, Expression and function of galectin-1 in adult neural stem cells, Cell Mol Life Sci 64(10):1254-8, 2007


Yamashita T, Ninomiya M, Acosta PH, García-Verdugo JM, Sunabori T, Sakaguchi M, Adachi K, Kojima T, Hirota Y, Kawase T, Araki N, Abe K, Okano H, Sawamoto K, Subventricular-zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum, J Neurosci 26(24):6627-36, 2006


Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H. A carbohydrate binding protein, Galectin-1, promotes proliferation of adult neural stem cells. PNAS 103(18):7112-7, 2006, Track II direct submission


Sakaguchi M, Sawamoto K, Shimazaki T, Kitamura T, Shibuya A, Okano H. A method for gene transfer, single isolation and in vitro assay for neural stem cells, Infl Regen 25(1), 50-54, 2005


Ishibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Ichinose S, Onodera M, Shimazaki T, Okano H, Mizusawa H. Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils., J Neurosci Res 78(2):215-23, 2004


Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M. Implantation of dendritic cells in the injured adult spinal cord results in activation of the endogenous neural/progenitor cells for de novo neurogenesis and axonal regeneration, leading to functional recovery, J Neurosci Res 76(4):453-65, 2004


Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, Darnell RB, Okano HJ, Okano H. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1, Neurosci Lett 358(3):157-60, 2004

坂口昌徳,喜田聡,PTSD の脳内機構 PTSD,恐怖記憶のメカニズムの動物実験に基づいた知見について,Clinical Neuroscience Vo.39 No.6,中外医学社,印刷中


菅谷佑樹、坂口昌徳,成体海馬の新生ニューロンが、睡眠中に記憶を固定化する,BRAIN and NERVE,医学書院,印刷中


坂口昌徳, 睡眠中の脳の再生能力が記憶を定着する,実験医学,「カレントトピックス」,羊土社,印刷中


小柳伊代, 新生ニューロンの低頻度活動が睡眠中の記憶固定化に必要, 神経科学ニュース, 2021Feb10, DOI: in printing

小柳伊代, 坂口昌徳, 睡眠中の新生ニューロンの活動とその記憶固定化への役割の解明, 神経化学トピックス, 2020Aug07, DOI 10.11481/topics1292017

長谷川 夏, 手塚太郎, 小柳 伊代, 坂口昌徳, レム睡眠中の脳の再生能力が記憶を定着させる – 睡眠中の記憶固定化のメカニズムにせまる, academistJournal, 2020Aug03

小柳伊代, 坂口昌徳, 8.1睡眠と記憶, 218-221, 睡眠学第2版, 朝倉書店, 2020


松崎舜, 坂口昌徳, 大西立顕, 信学技報NLP2018-123 118 143-148, 2019


松崎舜, 坂口昌徳, 大西立顕, 数理モデル化と問題解決 2018-MPS-120 1-6, 2018


小柳伊代, 李若詩, 藤中彩乃, 坂口昌徳, トラウマ記憶を弱めるには – マウスの記憶・睡眠研究から考えるPTSDケア, academistJournal, 2017Jul26

大石誠, 中島聡美, 坂口昌徳, The importance of acute intervention for preventing generalization in PTSD patients, 医学のあゆみ, 258(13):1209-1210, 2016


坂口昌徳, 脳内で新生するニューロンと中枢神経再生への応用, ブレインサイエンスレビュー, 廣川 信隆(編), クバプロ(出), 2016


Sakaguchi M, Sawamoto K, Okano H, Recombinant sugar binding proteins and their functional analysis: Galectin-1, GlycoPOD, JCGGDB, 2011


Imaizumi Y, Sakaguchi M, Hideyuki O, Galectin., Molecular Therapy, Sentan Igaku Sha, (6),pp80-81,2007 (in Japanese)

Sakaguchi M, Imaizumi Y, Sawamoto K, Okano H., The carbohydrate binding protein, Galectin-1 promotes proliferation of adult neural stem cells., Cell Engineering, Yodo Sha., 2006,(25),pp912-913(in Japanese)

Okano H, Kohyama J, Ohba H, Sakaguchi M,Tokunaga A, Shimazaki T and Okano HJ, Neural stem cells: Isolation and self-renewal. In Tissue Stem Cells; Biology & Applications, Taylor & Francis Group, LLC, New York,2006,pp55-70

Sakaguchi M, Sawamoto K, Okano H., Neuro-regenerative therapy - future therapeutic strategy, new medical lecture for nurse, Nakayama Shoten,2005,pp88-92(in Japanese)

Sakaguchi M, Sunabori K, Sawamoto K, Okano H., Development and regeneration of nervous system., Illustration map of development and regeneration, Yodo sha,2005,pp139-148(in Japanese)

Ninomiya M, Sawamoto K, Sakaguchi M, Okano H., Neural Stem Cells, Igaku no Ayumi, 2005,212(10), pp865-868(in Japanese)